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LYRIC (also known as Metadherin), a positive regulator of EMT, can promote ferroptosis by inhibiting the expression of GPX4 and SLC3A2 ( 3.4 Ferroptosis influences intestinal diseases by affecting metabolism Multiple metabolic pathways can influence cellular susceptibility to ferroptosis (Table 5)

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However, the protective effects of AHR activation must be balanced against the antagonistic IL-13/IL-4JAKSTAT6/STAT3 signaling pathway, which disrupts barrier integrity and promotes oxidative stress in AD